横浜市立大学　医学部　神経内科学・脳卒中医学教室　神経再生医学講座（竹居研究室）

横浜市立大学医学部
神経内科学・脳卒中医学教室
神経再生医学講座
（竹居研究室）
竹居光太郎：
〒236-0004
横浜市金沢区福浦3-9
TEL: 045-787-2781(教授室)
2769(研究室)
FAX:045-787-2769
  • 横浜市立大学
  • 横浜市立大学大学院 生命医科学研究科
  • 横浜市立大学大学院 医学研究科

研究業績

2024年

                1. Kurihara, Y., Kawaguchi, Y., Ohta, Y., Kawasaki, N. Fujita, Y., and Takei. K., Nogo receptor antagonist LOTUS promotes neurite outgrowth through its interaction with Teneurin-4. Cells, 13,1369. httpd.//doi.org/10.3390/cellls13161369 (2024).

2023年

                1. Ikeda, T., Takahashi, K., Higashi, M., Komiya, H., Ogasawara A., Kubota, S., Hashiguchi, S., Kunii, M., Tanaka, K., Tada, M., Doi, H., Takeuchi, H., Takei, K., and Tanaka, F. Lateral olfactory tract usher substance (LOTUS), an endogenous Nogo receptor antagonist, ameliorates disease progression in amyotrophic lateral sclerosis model mice. Cell Death Discovery 9 (1): 454 DOI 10.1035/s41420-023-01758-7 (2023).

                2.  Matsubayashi, J., Kawaguchi, Y., Kawakami, Y., and Takei, K. Brain-derived neurotrophic factor (BDNF) induces antagonistic action to Nogo signaling by the upregulation of lateral olfactory tract usher substance (LOTUS) expression. Journal of Neurochemistry, 164, 29-43 DOI:10.1111/jns.15732 (2023).

2022年

                1. Kawaguchi, Y., Matsubayashi, J., Kawakami, Y., Nishida, R., Kurihara, Y., and Takei, K. LOTUS suppresses amyloid beta-induced dendritic spine elimination through the blockade of amyloid β binding to PirB. Molecular Medicine, 28: 154-167 (https://doi.org/10.1186/s10020-022-00581-7) (2022).

2021年

                1. Nishida,R.,Kawaguchi,Y.,Matsubayashi,J.,Ishikawa,R.,Kida,S.,Takei,K. LOTUS,an endogenous Nogo receptor antagonist,is involved in synapse and memory formation.Scientfic  Reports,11 : 5085 (https://doi.org/10.1038/s41598-021-84106-y) (2021).
                2.  Ito, S., Nagoshi, N., Kamata, Y., Kojima, K., Nori, S., Matsumoto, M., Takei, K., Nakamura, M., and Okano, H. LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS/PC transplantation for contusive spinal cord injury. Stem Cell Reports, 16: 1-15 (https://doi.org/10.1016/j.semcr.2021.09.006) (2021).

2020年

                1. Kurihara,Y.,Takai,T.,and Takei,K., Nogo receptor antagonist LOTUS exerts suppression on axonal growth-inhibiting receptor PIR-B.J.Neurochemistry,155:285-299(2020).
                2. Takei,K. LOTUS as an endogenous protein converting the adult central nervous system environment from non-permissive to permissive to permissive for axonal regrowth after brain injury.Neuropathology,Doi:10.1111/neup.1235(2020).
                3. Ueno, R., Takase, H., Suenaga, J., Kishimoto, M., Kurihara, Y., Takei, K., Kawahara, N., and Yamamoto, T. Axonal regeneration and functional recovery driven by endogeneous Nogo receptor antagonist LOTUS in a rat model of unilateral pyramidotomy.Experimental Neurology, 323：113068, (2020)

2019年

                1. 高橋慶太, 竹内英之, 竹居光太郎, 田中章景 （2019）軸索関連分子LOTUSを応用した多発性硬化症の診断マーカー開発. Bio Clinica 34 (5): 60-64.

2018年

                1. Ito, S., Nagoshi, N., Tsuji, O., Shibata, S., Shinozaki, M., Kawabata, S., Kojima, K., Yasitake, K., Hirokawa, T., Matsumoto, M., Takei, K., Nakamura, M., and Okano, H. LOUTS inhibits neuronal apotpsos and promotes tract regeneration in contusive spinal cord injury model mice. eNeuro 2018; 10.1523/ENEURO.0303-18.2018 (2018)
                2. Hirokawa, T. and Takei, K. LOTUS protein, an endogenous Nogo receptor antagonist, converts a non-permissive to permissive brain environment for axonal regrowth. Neural Regeneration Research, 13(7): 1193-1194 (2018).
                3. Kawakami, Y., Saito, Y., Nakagawa, R., Kurihara, Y.,  and Takei, K. The soluble form of LOTUS inhibits Nogo receptor type 1-mediated signaling induced by B lymphocyte stimulator and chondroitin sulfate proteoglycans. Neuroscience Letters, 683: 61-68 (2018).
                4. Takei, K. Application of modified fluorophore-assisted light inactivation technique in nervous system cell and explant cultures. Medical Research Archives 6 (5): 1-11 (2018).
                5. Takahashi, K., Takeuchi, H., Kurihara, Y., Doi, H., Kunii, M., Tanaka, K., Nakamura, H., Fukai, R.,Tomita-Katsumoto, A., Tada, M., Higashiyama, Y., Joki, H., Koyano, S., Takei, K. and Tanaka, F. Cerebrospinal fluid level of Nogo receptor 1 antagonist lateral olfactory tract usher substance (LOTUS) correlates inversely with the extent of neuroinflammation. Journal of Neuroinflammation, 15:46 (DOI: 10.1186/s12974-1084)(2018)
                6. Kawakami, Y., Kurihara, Y., Saito, Y., Fujita, Y., Yamashita, T., and Takei, K. The soluble form of LOTUS inhibits Nogo receptor-mediated signaling by interfering with the interaction between Nogo receptor type 1 and p75 neurotrophin receptor. Journal of Neuroscience, 38(10): 2589-2604 (2018).
                7. 竹居光太郎（2018）光照射分子不活性化法（CALI/ FALI）. 顕微鏡学ハンドブック, 山科正平, 高田邦昭編, 朝倉書店, pp128-131.
                8. 竹居光太郎（2018）神経回路形成因子LOTUSの挑戦：神経発生機能と神経再生治療への展開. 実験医学 36(11): 1922-1928 (2018).
                9. 竹居光太郎（2018）神経再生を促す脳内環境制御因子LOTUS. 化学工業 69(8): 566-572.

2017年

                1. Kurihara, Y. and Takei, K., Regulation of lateral olfactory tract development by Nogo-A, Nogo receptor-1 and LOTUS proteins. Trends in Developmental Biology, 10: 41-47 (2017).
                2. Hirokawa, T. and Takei, K. LOTUS, a new natural agent providing a regenerative brain environment.Annals of Pharmacology and Pharmaceutics 2(19):1102, 1-3 (2017).
                3. Hirokawa, T., Zou, Y., Kurihara, Y., Jiang, Z., Sakakibara, Y., Ito, H., Funakoshi, K., Kawahara, N., Goshima, Y., Strittmatter, S.M., and Takei, K. Regulation of axonal regeneration by the level of function of endogenous Nogo receptor antagonist LOTUS. Scientific Reports,  7, 12119(doi:10.1038/s41598-017-12449-6)(2017).
                4. Takase, H., Kurihara, Y., Yokoyama, T., Kawahara, N, and Takei, K. LOTUS overexpression accelerates neuronal plasticity after focal brain ischemia in mice. PLOS One,12(9): e0184258 (2017).
                5. Kurihara, Y., Saito, Y., and Takei., K. Blockade of chondroitin sulfate proteoglycans-induced axonal growth inhibition by LOTUS. Neuroscience,356:265-274(2017).
                6. Goshima, Y., and Takei, K., Micro-CALI to investigate the localized role of the Semaphorin signaling component CRMP in axon growth. Methods in Molecular Biology, 1493:265-275(2017).
                7. 竹居光太郎（2017）光照射分子不活性化法（CALI法）によるタンパク質機能制御.生体の科学,　68(5):498-499
                8. 竹居光太郎（2017）神経回路形成因子LOTUS.　脳内環境辞典,　高橋良輔 他 編, メディカルドゥ社,　pp52-53

2016年

                1. Iketani, M., Yokoyama, T., Kurihara, Y., Strittmatter, S.M., Goshima, Y., Kawahara, N., and Takei, K. Axonal branching in lateral olfactory tract is promoted by Nogo signaling. Scientific Reports, 6: 39586 (DOI: 10.1038/srep39586 (2016).
                2. Ge, X., Ritter, S.Y. Tsang, K., Shi, R., Takei, K., and Aliprantis, A.O.  Sex-specific Protection of osteoarthritis by deleting cartilage acid protein 1. PloS One, DOI: 10.1371/journal.pone.0159157(2016).
                3. 高橋慶太, 田中章景, 竹居光太郎（2016）多発性硬化症の新規病勢診断マーカー.臨床神経科学（Clinical Neuroscience),　34（4）:484-485.
                4. 高橋慶太, 田中章景, 竹居光太郎（2016）軸索再生関連分子の多発性硬化症診断マーカーへの応用. Brain and Nerve,　68(1):82-89.

2015年

                1. Takahashi, K., Takei, K., and Tanaka, F. Association of multiple sclerosis with lateral olfactory tract usher substance (LOTUS), a possible endogenous inhibitor of axonal degeneration. Clinical and Experimental Neuroimmunology,　6：64-69（2015）.
                2. Takahashi, K., Tanaka, F., and Takei, K. LOTUS, a possible endogenous inhibitor of axonal degeneration, as a biomarker for multiple sclerosis. Neurodegerative Dsiease Manegement, 5（6）：469-472（doi：10.2217/nmt.15.47)(2015).
                3. Nagai, J., Kitamura, Y., Owada, K., Yamashita, N., Takei, K., Goshima, Y., and Ohshima. T.  Crmp4 deletion promotes recovery from spinal cord injury by neuroprotection and limited scar formation. Scientific Report, 5:8269(doi:10.1038/srep08269) (2015).
                4. Takahashi, K., Kurihara, Y., Suzuki, Y., Goshima, Y., Tanaka, F., and Takei, K. Association of cerebrospinal fluid levels of lateral olfactory usher substance protein with disease activity in multiple sclerosis. JAMA Neurology. 72(2): 176-179 DOI:10.1001/jamaneurol.(2015).
                5. Kurihara, Y., and Takei, K. LOTUS, a potent blocker of Nogo receptor causing inhibition of axonal growth. Neural Regeneration Research, 10(1): 46-18(2015).
                6. 竹居光太郎（2015）軸索再生阻害因子の制御による神経回路形成と神経再生. 脳神経系の再生医学, p85-90, 診断と治療社.
                7. 竹居光太郎（2015）神経回路形成因子LOTUSの機能に基づく神経系の再生医学的研究. 横浜医学 66(4):547-552.

2014年

                1. Kurihara, Y., Iketani, M., Ito,H., Nishiyama, K., Sakakibara, Y., Goshima, Y., and Takei, K. LOTUS suppresses axon growth inhibition by blocking interaction between Nogo receptor-1 and all four types of its ligand. Molecular Cellular Nueroscience, 61:211-218 (2014).
                2. Yamashita, N., Usui, H., Nakamura, F., Chen, S., Sasaki, Y., Hida, T., Suto, F., Taniguchi, M., Takei, K., and Goshima, Y. PlexinA4-dependent retrograde Semaphorin3A signaling regulates the dendritic localization of GluA2-containing AMPA receptors. Nature Communications, 5: 3424 DOI: 10.1038/ncomms4424 (2014).
                3. 竹居光太郎（2014）神経再生促進物質LOTUSの生理機能解析.　ブレインサイエンスレビュー2014, P149-164, クバプロ.

2013年

                1. 竹居光太郎（2013）哺乳類中枢神経系の新しい神経回路形成機構：神経束形成因子LOTUSの発見. 生化学 85:328-335.
                2. 栗原裕司, 竹居光太郎（2013）LOTUSによる神経回路形成機構. Annual Review 2013　神経,  p.63-67, 中外医学社.
                3. 竹居光太郎（2013）神経回路形成分子LOTUSの機能.　横浜医学, 64(4): 635-640.
                4. 竹居光太郎（2013）脳内環境制御による軸索再生：LOTUSによる軸索再生. Bio Clinica 28(13): 43-48, 北隆館.

2012年

                1. Kurihara, Y., Arie, Y., Iketani, M., Ito, H., Nishiyama, K., Sato, Y., Nakamura, F., Mizuki, N., Goshima, Y., Takei, K. The carboxyl-terminal region of Crtac1b/LOTUS acts as a functional domain in endogenous antagonism to Nogo receptor-1. Biochemical and Biophysical Research Communications, 418：390-395 (2012).
                2. Iketani, M., Iizuka, A., Sengoku, k., Kurihara, Y., Nakamura, F., Sasaki, Y., Sato, Y., Yamane, M., Matsushita, M.,  Nairn A.C., Takamatsu, K., Goshima, Y., and Takei, K. Regulation of neurite outgrowth mediated by localized phosphorylation of protein translational factor eEF2 in growth cones. Developmental Neurbiology, 73(3): 230-246 DOI 10.1002/dneu.22058 (2012)
                3. Higurashi, M., Iketani, M., Takei, K., Yamashita, N., Aoki, R., Kawahara, N., and Goshima, Y. Localized role of CRMP1 and CRMP2 in eurite outgrowth and growthcone steering. Developmental Neurobiology, 72:1528-1540 DOI 10.1002/dneu.22017 (2012)
                4. 竹居光太郎（2012）光照射分子不活性化法（CALI法）. 日本薬理学会雑誌（Folia Pharmacology Japan）140: 226-230
                5. 池谷真澄, 栗原裕司, 佐藤泰史, 五嶋良郎, 竹居光太郎（2012）内在性Nogo受容体アンタゴニストLOTUSの嗅索形成における生理的役割. 実験医学 30(3): 479-482.

2011年

                1. Sato, Y., Iketani, M., Kurihara, Y., Yamaguchi, M., Yamashita, N., Nakamura, F., Arie, Y., Kawasaki, T., Hirata, T., Abe, T., Kiyonari, H., Strittmatter, S.M., Goshima, Y., and Takei, K. Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation. Science, 333：769-773 (2011).
                2. 佐藤泰史, 池谷真澄, 竹居光太郎（2011）LOTUSは内在性のNogo受容体-1アンタゴニストである. ライフサイエンス新着論文レビュー（http://first.lifessciencedb.jp/archives/3457）.

2009年

                1. Iketani, M., Imaizumi, C., Nakamura, F., Jeromin, A., Mikoshiba, K., Goshima, Y., and Takei, K.  Regulation of neurite outgrowth mediated by neuronal calcium sensor-1 and inositol 1,4,5-trisphosphate receptor in nerve growth cones. Neuroscience, 163(3): 743-752 (2009).
                2. Fuchikawa, T., Nakamura, F., Fukuda, N., Takei, K., and Goshima, Y.  Protein tyrosine phosphate SHP2 is involved in Semaphorin 4D-inducued axon repulsion. Biochemical and Biophysical Research Communications, 385：6-10 (2009).
                3. Arie, Y. Iketani, M., Takamatsu, K., Mikoshiba, K., Goshima, Y, and Takei, K.  Developmental changes in the regulation of calcium-dependent neurite outgrowth. Biochemical and Biophysical Research Communications, 379: 11-15  (2009).
                4. 竹居光太郎（2009）光照射による分子機能阻害法：開発適用の歴史と新たな幕開け、蛋白質核酸酵素53（3）：284-291, 共立出版.

2008年

                1. Yamaguchi, J., Nakamura, F., Aihara, M., Yamashita, N., Usui, H., Hida, T., Takei, K., Nagashima, Y., Ikezawa, Z., and Goshima, Y. Semaphorin3A alleviates skin lesion and scratching behavior in NC/Nga mice, an atopic dermatitis model.  J. Investigative Dermatology, 128: 2842-2849 (2008).
                2. Abe, T.K., Honda, T., Takei, K., Mikoshiba, K., Hoffman-Kim, D., Jay, D.G., and Kuwano, R. Dynactin is essential for growth cone advance. Biochemical and Biophysical Research Communications, 372: 418-422 (2008).

2007年

                1. Yamashita, N., Morita, A., Uchida, Y., Nakamura, F., Usui, H., Ohshima, T., Taniguchi, M., Honnorat, J., Thomasset, N., Takei, K., Takahashi, T., Kolattukudy, P., and Goshima, Y.  Regulation of spine development by semaphorin3A through cyclin-dependent kinase 5 phosphorylation of collapsing response mediator protein 1.  J. Neuroscience, 27： 12546-12554 (2007).
                2. Iizuka, A., Sengoku, K., Iketani, M., Nakamura, F., Sato, Y., Matsushita, M., Nairn, A.C., Takamatsu, K., Goshima, Y., and Takei, K.  Calcium-induced synergistic inhibition of a translational factor eEF2 in nerve growth cones.  Biochemical and Biophysical Research Communications, 353： 244-250 (2007).

2006年

                1. Yamashita, N., Uchida, Y., Morita, A., Ohshima, T., Hirai, S., Nakamura, F., Usui, H., Taniguchi, M., Mikoshiba, K., Honnorad, J., Kolattukudy, P., Thomasset, N., Takei, K., Takahashi, T., and Goshima, Y.  CRMP1 mediates Reelin signaling in cortical neuronal migration. J. Neuroscience, 26: 13357-13362 (2006).
                2. Morita, A., Yamashita, N., Sasaki, Y., Uchida, Y., Nakajima, O., Nakamura, F., Yagi, T., Taniguchi, M., Usui, H., Katoh-Semba, R., Takei, K., and Goshima, Y.  Regulation of dendritic branching and spine maturation by Semaphorin3A-Fyn Signaling. J. Neuroscience, 26: 2971-2980 (2006).
                3. Nakajima, O., Nakamura, F., Yamashita, N., Tomita, Y., Suto, F., Okada, T., Iwamattsu, A., Kondo, E., Fujisawa, H., Takei, K., and Goshima, Y.  FKBP133: A novel mouse FK-506 binding protein homolog alters growth cone morphology. Biochemical and Biophysical Research Communications, 346: 140-149 (2006).
                4. 中島央美, 中村史雄, 須藤文和, 岡田貴子, 岩松明彦, 藤澤肇, 竹居光太郎, 五嶋良郎（2006）新規分子KIAA0674の同定と発現解析.　横浜医学 57: 85-93.
                5. 中村史雄, 竹居光太郎, 五嶋良郎（2006）軸索ガイダンス分子による神経成長円錐の細胞骨格制御、蛋白質核酸酵素51：733-741, 共立出版.

2005年

                1. Uchida, Y., Ohshima, T., Sasaki, Y., Suzuki, H., Yanai, S., Yamashita, N., Nakamura, F., Takei, K., Ihara, Y., Mikoshiba, K., Kolattukudy, P., Honnorat, J., and Goshima, Y.  Cdk5 and GSK3β sequentiaaly phosphorylate CRMP2 in Semaphorin-3A signaling: Implication of common phosphorylating mechanism underlying axon guidance and Alzheimer disease. Genes to Cells, 10: 165-179 (2005).

2004年

                1. Li, C., Sasaki, Y., Takei, K., Yamamoto, H., Shouji, M., Sugiyama, Y., Kawakami, T., Nakamura, F., Yagi, T., Ohshima, T., and Goshima, Y.  Correlation between Sema3A-induced facilitation of axonal transport and local activation of a translation initiation factor eIF-4E.  J. Neuroscience, 24: 6161-6170 (2004).
                2. 竹居光太郎（2004）レーザー分子不活性化法 (CALI法)、レーザーハンドブック第２版、レーザー学会編、オーム社.

2003年

                1. Cheng, Q., Sasaki, Y. Shoji, M., Sugiyama, Y., Tanaka, H., Nakayama, T., Mizuki, N., Nakamura, F., Takei, K., and Goshima, Y.  Cdk5/p35 and Rho-kinase mediate Ephrin-A5-induced signaling in retinal ganglion cells. 　Molecular and Cellular Neuroscience, 24: 632-645 (2003).
                2. Tamaru, T., Isojima, Y., Horst, G.T.J., Takei, K., Nagai, K., and Takamatsu, K.  Nucleous cytoplasmic shuttling and phosphorylation of BMAL1 are regulated by circadian clock in cultured fibloblasts.  Genes to Cell s, 8: 973-983 (2003).
                3. Kikuchi, S., Fujimoto, K., Kitagawa, N., Fuchikawa, T., Abe, M., Oka, K., Takei, K., and Tomita, M.  Kinetic simulation of bistability of signal transduction system in hippocampal long-term potentiation.  Neural Networks, 16: 1389-1398 (2003).

2003年以前

                  2003年以前の研究業績は
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