Takei,K.LOTUS as an endogenous protein converting the adult central nervous system environment from non-permissive to permissive to permissive for axonal regrowth after brain injury.Neuropathology,Doi:10.1111/neup.1235(2020).
Ueno, R., Takase, H., Suenaga, J., Kishimoto, M., Kurihara, Y., Takei, K., Kawahara, N., and Yamamoto, T. Axonal regeneration and functional recovery driven by endogeneous Nogo receptor antagonist LOTUS in a rat model of unilateral pyramidotomy.Experimental Neurology, 323:113068, (2020)
2019年
高橋慶太, 竹内英之, 竹居光太郎, 田中章景 (2019)軸索関連分子LOTUSを応用した多発性硬化症の診断マーカー開発. Bio Clinica 34 (5): 60-64.
2018年
Ito, S., Nagoshi, N., Tsuji, O., Shibata, S., Shinozaki, M., Kawabata, S., Kojima, K., Yasitake, K., Hirokawa, T., Matsumoto, M., Takei, K., Nakamura, M., and Okano, H. LOUTS inhibits neuronal apotpsos and promotes tract regeneration in contusive spinal cord injury model mice. eNeuro 2018; 10.1523/ENEURO.0303-18.2018 (2018)
Hirokawa, T. and Takei, K. LOTUS protein, an endogenous Nogo receptor antagonist, converts a non-permissive to permissive brain environment for axonal regrowth. Neural Regeneration Research, 13(7): 1193-1194 (2018).
Kawakami, Y., Saito, Y., Nakagawa, R., Kurihara, Y., and Takei, K. The soluble form of LOTUS inhibits Nogo receptor type 1-mediated signaling induced by B lymphocyte stimulator and chondroitin sulfate proteoglycans. Neuroscience Letters, 683: 61-68 (2018).
Takei, K. Application of modified fluorophore-assisted light inactivation technique in nervous system cell and explant cultures. Medical Research Archives 6 (5): 1-11 (2018).
Takahashi, K., Takeuchi, H., Kurihara, Y., Doi, H., Kunii, M., Tanaka, K., Nakamura, H., Fukai, R.,Tomita-Katsumoto, A., Tada, M., Higashiyama, Y., Joki, H., Koyano, S., Takei, K. and Tanaka, F. Cerebrospinal fluid level of Nogo receptor 1 antagonist lateral olfactory tract usher substance (LOTUS) correlates inversely with the extent of neuroinflammation. Journal of Neuroinflammation, 15:46 (DOI: 10.1186/s12974-1084)(2018)
Kawakami, Y., Kurihara, Y., Saito, Y., Fujita, Y., Yamashita, T., and Takei, K. The soluble form of LOTUS inhibits Nogo receptor-mediated signaling by interfering with the interaction between Nogo receptor type 1 and p75 neurotrophin receptor. Journal of Neuroscience, 38(10): 2589-2604 (2018).
Kurihara, Y. and Takei, K., Regulation of lateral olfactory tract development by Nogo-A, Nogo receptor-1 and LOTUS proteins. Trends in Developmental Biology, 10: 41-47 (2017).
Hirokawa, T. and Takei, K. LOTUS, a new natural agent providing a regenerative brain environment.Annals of Pharmacology and Pharmaceutics 2(19):1102, 1-3 (2017).
Hirokawa, T., Zou, Y., Kurihara, Y., Jiang, Z., Sakakibara, Y., Ito, H., Funakoshi, K., Kawahara, N., Goshima, Y., Strittmatter, S.M., and Takei, K. Regulation of axonal regeneration by the level of function of endogenous Nogo receptor antagonist LOTUS. Scientific Reports, 7, 12119(doi:10.1038/s41598-017-12449-6)(2017).
Takase, H., Kurihara, Y., Yokoyama, T., Kawahara, N, and Takei, K. LOTUS overexpression accelerates neuronal plasticity after focal brain ischemia in mice. PLOS One,12(9): e0184258 (2017).
Kurihara, Y., Saito, Y., and Takei., K. Blockade of chondroitin sulfate proteoglycans-induced axonal growth inhibition by LOTUS. Neuroscience,356:265-274(2017).
Goshima, Y., and Takei, K., Micro-CALI to investigate the localized role of the Semaphorin signaling component CRMP in axon growth. Methods in Molecular Biology, 1493:265-275(2017).
Iketani, M., Yokoyama, T., Kurihara, Y., Strittmatter, S.M., Goshima, Y., Kawahara, N., and Takei, K. Axonal branching in lateral olfactory tract is promoted by Nogo signaling. Scientific Reports, 6: 39586 (DOI: 10.1038/srep39586 (2016).
Ge, X., Ritter, S.Y. Tsang, K., Shi, R., Takei, K., and Aliprantis, A.O. Sex-specific Protection of osteoarthritis by deleting cartilage acid protein 1. PloS One, DOI: 10.1371/journal.pone.0159157(2016).
高橋慶太, 田中章景, 竹居光太郎(2016)軸索再生関連分子の多発性硬化症診断マーカーへの応用. Brain and Nerve, 68(1):82-89.
2015年
Takahashi, K., Takei, K., and Tanaka, F. Association of multiple sclerosis with lateral olfactory tract usher substance (LOTUS), a possible endogenous inhibitor of axonal degeneration. Clinical and Experimental Neuroimmunology, 6:64-69(2015).
Takahashi, K., Tanaka, F., and Takei, K. LOTUS, a possible endogenous inhibitor of axonal degeneration, as a biomarker for multiple sclerosis. Neurodegerative Dsiease Manegement, 5(6):469-472(doi:10.2217/nmt.15.47)(2015).
Nagai, J., Kitamura, Y., Owada, K., Yamashita, N., Takei, K., Goshima, Y., and Ohshima. T. Crmp4 deletion promotes recovery from spinal cord injury by neuroprotection and limited scar formation. Scientific Report, 5:8269(doi:10.1038/srep08269) (2015).
Takahashi, K., Kurihara, Y., Suzuki, Y., Goshima, Y., Tanaka, F., and Takei, K. Association of cerebrospinal fluid levels of lateral olfactory usher substance protein with disease activity in multiple sclerosis. JAMA Neurology. 72(2): 176-179 DOI:10.1001/jamaneurol.(2015).
Kurihara, Y., and Takei, K. LOTUS, a potent blocker of Nogo receptor causing inhibition of axonal growth. Neural Regeneration Research, 10(1): 46-18(2015).
Kurihara, Y., Iketani, M., Ito,H., Nishiyama, K., Sakakibara, Y., Goshima, Y., and Takei, K. LOTUS suppresses axon growth inhibition by blocking interaction between Nogo receptor-1 and all four types of its ligand. Molecular Cellular Nueroscience, 61:211-218 (2014).
Yamashita, N., Usui, H., Nakamura, F., Chen, S., Sasaki, Y., Hida, T., Suto, F., Taniguchi, M., Takei, K., and Goshima, Y. PlexinA4-dependent retrograde Semaphorin3A signaling regulates the dendritic localization of GluA2-containing AMPA receptors. Nature Communications, 5: 3424 DOI: 10.1038/ncomms4424 (2014).
竹居光太郎(2013)脳内環境制御による軸索再生:LOTUSによる軸索再生. Bio Clinica 28(13): 43-48, 北隆館.
2012年
Kurihara, Y., Arie, Y., Iketani, M., Ito, H., Nishiyama, K., Sato, Y., Nakamura, F., Mizuki, N., Goshima, Y., Takei, K. The carboxyl-terminal region of Crtac1b/LOTUS acts as a functional domain in endogenous antagonism to Nogo receptor-1. Biochemical and Biophysical Research Communications, 418:390-395 (2012).
Iketani, M., Iizuka, A., Sengoku, k., Kurihara, Y., Nakamura, F., Sasaki, Y., Sato, Y., Yamane, M., Matsushita, M., Nairn A.C., Takamatsu, K., Goshima, Y., and Takei, K. Regulation of neurite outgrowth mediated by localized phosphorylation of protein translational factor eEF2 in growth cones. Developmental Neurbiology, 73(3): 230-246 DOI 10.1002/dneu.22058 (2012)
Higurashi, M., Iketani, M., Takei, K., Yamashita, N., Aoki, R., Kawahara, N., and Goshima, Y. Localized role of CRMP1 and CRMP2 in eurite outgrowth and growthcone steering. Developmental Neurobiology, 72:1528-1540 DOI 10.1002/dneu.22017 (2012)
Iketani, M., Imaizumi, C., Nakamura, F., Jeromin, A., Mikoshiba, K., Goshima, Y., and Takei, K. Regulation of neurite outgrowth mediated by neuronal calcium sensor-1 and inositol 1,4,5-trisphosphate receptor in nerve growth cones. Neuroscience, 163(3): 743-752 (2009).
Fuchikawa, T., Nakamura, F., Fukuda, N., Takei, K., and Goshima, Y. Protein tyrosine phosphate SHP2 is involved in Semaphorin 4D-inducued axon repulsion. Biochemical and Biophysical Research Communications, 385:6-10 (2009).
Arie, Y. Iketani, M., Takamatsu, K., Mikoshiba, K., Goshima, Y, and Takei, K. Developmental changes in the regulation of calcium-dependent neurite outgrowth. Biochemical and Biophysical Research Communications, 379: 11-15 (2009).
Yamaguchi, J., Nakamura, F., Aihara, M., Yamashita, N., Usui, H., Hida, T., Takei, K., Nagashima, Y., Ikezawa, Z., and Goshima, Y. Semaphorin3A alleviates skin lesion and scratching behavior in NC/Nga mice, an atopic dermatitis model. J. Investigative Dermatology, 128: 2842-2849 (2008).
Abe, T.K., Honda, T., Takei, K., Mikoshiba, K., Hoffman-Kim, D., Jay, D.G., and Kuwano, R. Dynactin is essential for growth cone advance. Biochemical and Biophysical Research Communications, 372: 418-422 (2008).
2007年
Yamashita, N., Morita, A., Uchida, Y., Nakamura, F., Usui, H., Ohshima, T., Taniguchi, M., Honnorat, J., Thomasset, N., Takei, K., Takahashi, T., Kolattukudy, P., and Goshima, Y. Regulation of spine development by semaphorin3A through cyclin-dependent kinase 5 phosphorylation of collapsing response mediator protein 1. J. Neuroscience, 27: 12546-12554 (2007).
Iizuka, A., Sengoku, K., Iketani, M., Nakamura, F., Sato, Y., Matsushita, M., Nairn, A.C., Takamatsu, K., Goshima, Y., and Takei, K. Calcium-induced synergistic inhibition of a translational factor eEF2 in nerve growth cones. Biochemical and Biophysical Research Communications, 353: 244-250 (2007).
2006年
Yamashita, N., Uchida, Y., Morita, A., Ohshima, T., Hirai, S., Nakamura, F., Usui, H., Taniguchi, M., Mikoshiba, K., Honnorad, J., Kolattukudy, P., Thomasset, N., Takei, K., Takahashi, T., and Goshima, Y. CRMP1 mediates Reelin signaling in cortical neuronal migration. J. Neuroscience, 26: 13357-13362 (2006).
Morita, A., Yamashita, N., Sasaki, Y., Uchida, Y., Nakajima, O., Nakamura, F., Yagi, T., Taniguchi, M., Usui, H., Katoh-Semba, R., Takei, K., and Goshima, Y. Regulation of dendritic branching and spine maturation by Semaphorin3A-Fyn Signaling. J. Neuroscience, 26: 2971-2980 (2006).
Nakajima, O., Nakamura, F., Yamashita, N., Tomita, Y., Suto, F., Okada, T., Iwamattsu, A., Kondo, E., Fujisawa, H., Takei, K., and Goshima, Y. FKBP133: A novel mouse FK-506 binding protein homolog alters growth cone morphology. Biochemical and Biophysical Research Communications, 346: 140-149 (2006).
Uchida, Y., Ohshima, T., Sasaki, Y., Suzuki, H., Yanai, S., Yamashita, N., Nakamura, F., Takei, K., Ihara, Y., Mikoshiba, K., Kolattukudy, P., Honnorat, J., and Goshima, Y. Cdk5 and GSK3β sequentiaaly phosphorylate CRMP2 in Semaphorin-3A signaling: Implication of common phosphorylating mechanism underlying axon guidance and Alzheimer disease. Genes to Cells, 10: 165-179 (2005).
2004年
Li, C., Sasaki, Y., Takei, K., Yamamoto, H., Shouji, M., Sugiyama, Y., Kawakami, T., Nakamura, F., Yagi, T., Ohshima, T., and Goshima, Y. Correlation between Sema3A-induced facilitation of axonal transport and local activation of a translation initiation factor eIF-4E. J. Neuroscience, 24: 6161-6170 (2004).
Cheng, Q., Sasaki, Y. Shoji, M., Sugiyama, Y., Tanaka, H., Nakayama, T., Mizuki, N., Nakamura, F., Takei, K., and Goshima, Y. Cdk5/p35 and Rho-kinase mediate Ephrin-A5-induced signaling in retinal ganglion cells. Molecular and Cellular Neuroscience, 24: 632-645 (2003).
Tamaru, T., Isojima, Y., Horst, G.T.J., Takei, K., Nagai, K., and Takamatsu, K. Nucleous cytoplasmic shuttling and phosphorylation of BMAL1 are regulated by circadian clock in cultured fibloblasts. Genes to Cell s, 8: 973-983 (2003).
Kikuchi, S., Fujimoto, K., Kitagawa, N., Fuchikawa, T., Abe, M., Oka, K., Takei, K., and Tomita, M. Kinetic simulation of bistability of signal transduction system in hippocampal long-term potentiation. Neural Networks, 16: 1389-1398 (2003).